Validation of a SIMIND Monte Carlo modelled gamma camera for Iodine-123 and Iodine-131 imaging

Rabbit internal dosimetry for iodine-131 using GATE Monte Carlo simulation code: a preclinical trial

Introduction: One of the main concerns in administration of radiotracers, especially in therapeutic arm, is the amount of delivered dose to the different organs. Individual variations of anatomy, physiology and underlying pathology in the patients lead to alteration of administered activity. In the current study we preclinically applied internal dosimetry using an animal mod...

Derivation and validation of a sensitivity formula for knife-edge slit gamma camera: A theoretical and Monte Carlo simulation study

Introduction: Gamma cameras are proposed for online range verification and treatment monitoring in proton therapy.  An Analytical formula was derived and validated for sensitivity of a slit collimator based on the photon fluence concept. Methods: Fluence formulation was generalized for photons distribution function and solved for high-energy point sources. The...

Measurement of iodine-123 thyroid uptake using a gamma camera with LEAP collimator.

OBJECTIVE This study compared the 123I thyroid uptake measurements obtained from a gamma camera fitted with a low-energy all-purpose (LEAP) collimator to those obtained from a thyroid uptake probe and gamma camera fitted with a pinhole (PH) collimator. METHODS Thirty-one patients (27 female and 4 male patients) were studied for comparison between a probe and a gamma camera fitted with LEAP co...

Synthesis and biodistribution study of a chlorotoxin derivative peptide labeled with 131- iodine for tumor therapy

Background: Chlorotoxin is a 36-amino acid peptide found in the venom of the Leiurus quinquestriatus which blocks small-conductance chloride channels. Chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. Thus chlorotoxin derivative was labeled with 131I for further investigation. Materials and...

Iodine-131 and Thyroid Function